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AIM-01™ is a cutting-edge supplement designed to improve healthspan through advanced inflammation management.

* all studies and research are linked to below

Science Page

AIM:01’s advanced formulation slows premature cellular aging and helps to prevent the onset of age-related diseases and chronic conditions.

What is inflammation?

Inflammation is our body’s first line of defense.

Following an infection or cellular injury, our immune system activates an inflammatory response to eliminate threats like bacteria and viruses. Immune cells quickly identify and terminate damage-associated molecular patterns (DAMPs) that are released during cellular injury or infection.

Our bodies need the immune system’s temporary inflammatory response to survive. But when the immune system fails to downregulate this activated response, inflammation quickly turns from defender to attacker.

Chronic inflammation is the result of the immune system turning on itself. With no threats or foreign invaders to fight off, the same processes that eliminate threatening cells begin to attack healthy tissues and organs.

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50% of all deaths are attributable to inflammation-related diseases.*Netea MG, Balkwill F, Chonchol M, et al. A guiding map for inflammation.
GBD 2017 Causes of Death Collaborators. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories

When left unchecked, chronic inflammation can lead to deadly diseases and lifelong health conditions.

Diseases

  • Ischemic heart disease
  • Stroke
  • Cancer
  • Diabetes
  • Chronic Kidney Disease
  • Inflammatory Bowel diseases
  • Neurodegenerative disorders
  • Chronic obstructive pulmonary disease

Conditions

  • Chronic pain
  • Mood and anxiety disorders
  • Acne
  • Eczema
  • Asthma
  • Psoriasis
  • Autoimmune disorders

AIM-01 is the world’s most innovative inflammation-regulating daily supplement. It’s advanced formulation features 3 patented ingredients that have been clinically studied to reduce chronic inflammation and reverse the markers of biological aging.

C3 Reduct®

Tetrohydrocurcumin is more easily absorbed by the intestines and accessed by cells than traditional curcumin.

Curcumin C3 Reduct (Tetrohydrocurcumin) is a modified and patented version of Curcumin. The potency of this plant-based compound is significantly more than traditional Curcumin and is more readily absorbed by the intestines.

Benefit
    The effects of Curcumin C3 Reduct:
  • Eliminates harmful molecules called Reactive Oxygen Species (ROS)
  • Suppresses the activity of pro-inflammatory molecules
  • Acts as a potent antioxidant to protect against inflammation
  • Reduces inflammation-related tissue damage
    • The benefits of Curcumin C3 Reduct:
  • Reduces inflammation
  • Improves joint range of motion

Mitoprime™

Introducing MitoPrime, a powerful, naturally occurring, energy-boosting antioxidant.

This patented formulation of L-ergothioneine, is more easily absorbed and utilized by cells than traditional formulations of ergothioneine. As an amino acid with high antioxidant potency, MitoPrime has proven its efficacy in protecting DNA from oxidative damage and preventing cell-death. Together, these preventative functions reduce age-related cognitive decline.

Benefit
    The effects of MitoPrime:
  • Removes excess inflammatory molecules that accumulate in injured tissues
  • Helps to prevent cell death
  • Helps to increase production of anti-inflammatory molecules
  • Helps to combat pain signaling
    • The Benefits of MitoPrime:
  • Relieves pain
  • Improves joint range of motion
  • Defends against the development of chronic pain, cardiovascular disease, diabetes, and Alzheimer’s.

GlucoVantage®

GlucoVantage/Dihydroberberine is a first-of-its-kind formulation that improves insulin sensitivity and supports healthy body composition.

Dihydroberberine is a naturally occurring derivative of Berberine that is significantly more bioavailable. This plant-based molecule plays an important role in preventing metabolic disorders and supporting a healthy body:fat ratio. It activates AMP-activated protein kinase, which is an enzyme in the body that stops the growth of fat cells, improves how fat is used for energy, and enhances cardiovascular health.

Benefit
    The effects of GlucoVantage:
  • Improves insulin sensitivity
  • Enhances the conversion of fat into energy
  • Inhibits the growth of fat cells
  • Suppresses pro-inflammatory signaling molecules
    • The Benefits of GlucoVantage:
  • Supports healthy body weight and waist circumference
  • Helps to balance blood glucose levels
  • Defends against development of inflammatory conditions, including: ulcerative colitis, diabetes, cancer.

trans-Resveratrol™

trans-Resveratrol is an essential anti-inflammatory plant-based compound that supports anti-aging by restoring cognitive impairment and boosting longevity.

Aging fans the flames of inflammation, but compounds like Resveratrol fight inflammation by blocking pro-inflammatory signaling molecules and enhancing enzymes that protect against inflammatory conditions.

  • Helps block pro-inflammatory signaling molecules
  • Enhances enzymes associated with longevity, like SIRT1
  • Aids release of cardioprotective, anticancer, neuroprotective and antidiabetic effects
  • Helps protect against inflammatory-induced conditions including arthritis and neuroinflammation
  • Helps prevent obesity and regulate cholesterol
  • Helps extend human healthspan

Ginger root extract®

Ginger root extract to reduce symptoms associated with chronic inflammation.

For centuries, herbal medicine practitioners have relied on ginger root extract’s anti-inflammatory properties to manage pain, cognition, and mobility. Ginger root extra suppresses the production of pro-inflammatory molecules and regulates glucose fluctuation.

Protects against:
  • Asthma
  • Diabetes
  • Arthritis
  • Alzheimer's
  • Crohn's Disease
  • Osteoporosis

Vitamin B12™

Vitamin B12 is an essential molecule for enhancing energy and boosting athletic performance.

Vitamin B12 helps enzymes carry out the process of converting food into energy. But as we age, our bodies grow deficient in B12, which can lower our energy levels, affect our metabolism, and contribute to cognitive impairment.

Benefit
  • Helps the body maintain energy
  • Helps prevent cognitive impairment
  • Helps reduce joint pain
  • Helps prevent anemia

  • View Studies and Research +

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    2. Tian X, Cioccoloni G, Sier JH, Naseem KM, Thorne JL, Moore JB. Ergothioneine supplementation in people with metabolic syndrome (ErgMS): protocol for a randomised, double-blind, placebo-controlled pilot study. Pilot Feasibility Stud. 2021;7(1):193. Published 2021 Oct 29. doi:10.1186/s40814-021-00929-6
    3. Benson KF, Ager DM, Landes B, Aruoma OI, Jensen GS. Improvement of joint range of motion (ROM) and reduction of chronic pain after consumption of an ergothioneine-containing nutritional supplement. Prev Med. 2012;54 Suppl:S83-S89. doi:10.1016/j.ypmed.2012.02.001
    4. Mobasheri A, Henrotin Y, Biesalski HK, Shakibaei M. Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health. Int J Mol Sci. 2012;13(4):4202-4232. doi:10.3390/ijms13044202
    5. Abbud W, Habinowski S, Zhang JZ, et al. Stimulation of AMP-activated protein kinase (AMPK) is associated with enhancement of Glut1-mediated glucose transport. Arch Biochem Biophys. 2000;380(2):347-352. doi:10.1006/abbi.2000.1935
    6. Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 2008;57(5):712-717. doi:10.1016/j.metabol.2008.01.013
    7. Feng, R., Shou, JW., Zhao, ZX. et al. Transforming berberine into its intestine-absorbable form by the gut microbiota. Sci Rep 5, 12155 (2015). https://doi.org/10.1038/srep12155
    8. Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol. 2009;41(1):40-59. doi:10.1016/j.biocel.2008.06.010
    9. Panahi Y, Hosseini MS, Khalili N, et al. Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: A post-hoc analysis of a randomized controlled trial. Biomed Pharmacother. 2016;82:578-582. doi:10.1016/j.biopha.2016.05.037
    10. Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, et al. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clin Interv Aging. 2014;9:451-458. Published 2014 Mar 20. doi:10.2147/CIA.S58535
    11. Singh S, Aggarwal BB. Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected] [published correction appears in J Biol Chem 1995 Dec 15;270(50):30235]. J Biol Chem. 1995;270(42):24995-25000. doi:10.1074/jbc.270.42.24995
    12. Nakamura Y, Ohto Y, Murakami A, Osawa T, Ohigashi H. Inhibitory effects of curcumin and tetrahydrocurcuminoids on the tumor promoter-induced reactive oxygen species generation in leukocytes in vitro and in vivo. Jpn J Cancer Res. 1998;89(4):361-370. doi:10.1111/j.1349-7006.1998.tb00572.x
    13. Murugan P, Pari L. Influence of tetrahydrocurcumin on hepatic and renal functional markers and protein levels in experimental type 2 diabetic rats. Basic Clin Pharmacol Toxicol. 2007;101(4):241-245. doi:10.1111/j.1742-7843.2007.00109.x
    14. Pari L, Murugan P. Protective role of tetrahydrocurcumin against erythromycin estolate-induced hepatotoxicity. Pharmacol Res. 2004;49(5):481-486. doi:10.1016/j.phrs.2003.11.005
    15. Chuengsamarn S, Rattanamongkolgul S, Luechapudiporn R, Phisalaphong C, Jirawatnotai S. Curcumin extract for prevention of type 2 diabetes. Diabetes Care. 2012;35(11):2121-2127. doi:10.2337/dc12-0116
    16. Panahi Y, Hosseini MS, Khalili N, et al. Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: A post-hoc analysis of a randomized controlled trial. Biomed Pharmacother. 2016;82:578-582. doi:10.1016/j.biopha.2016.05.037
    17. Tan J, Thiboutot D, Popp G, et al. Randomized phase 3 evaluation of trifarotene 50 μg/g cream treatment of moderate facial and truncal acne. J Am Acad Dermatol. 2019;80(6):1691-1699. doi:10.1016/j.jaad.2019.02.044
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    21. Aggarwal BB, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol. 2009;41(1):40-59. doi:10.1016/j.biocel.2008.06.010
    22. Cheah IK, Halliwell B. Ergothioneine; antioxidant potential, physiological function and role in disease. Biochim Biophys Acta. 2012;1822(5):784-793. doi:10.1016/j.bbadis.2011.09.017
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    25. Cheah IK, Tang RM, Yew TS, Lim KH, Halliwell B. Administration of Pure Ergothioneine to Healthy Human Subjects: Uptake, Metabolism, and Effects on Biomarkers of Oxidative Damage and Inflammation. Antioxid Redox Signal. 2017;26(5):193-206. doi:10.1089/ars.2016.6778
    26. Rahman I, Gilmour PS, Jimenez LA, Biswas SK, Antonicelli F, Aruoma OI. Ergothioneine inhibits oxidative stress- and TNF-alpha-induced NF-kappa B activation and interleukin-8 release in alveolar epithelial cells. Biochem Biophys Res Commun. 2003;302(4):860-864. doi:10.1016/s0006-291x(03)00224-9
    27. Li L, Li J, Gao M, et al. Interleukin-8 as a Biomarker for Disease Prognosis of Coronavirus Disease-2019 Patients. Front Immunol. 2021;11:602395. Published 2021 Jan 8. doi:10.3389/fimmu.2020.602395
    28. Lam-Sidun D, Peters KM, Borradaile NM. Mushroom-Derived Medicine? Preclinical Studies Suggest Potential Benefits of Ergothioneine for Cardiometabolic Health. Int J Mol Sci. 2021;22(6):3246. Published 2021 Mar 23. doi:10.3390/ijms22063246
    29. Repine JE, Elkins ND. Effect of ergothioneine on acute lung injury and inflammation in cytokine insufflated rats. Prev Med. 2012;54 Suppl(Suppl):S79-S82. doi:10.1016/j.ypmed.2011.12.006
    30. Benson KF, Ager DM, Landes B, Aruoma OI, Jensen GS. Improvement of joint range of motion (ROM) and reduction of chronic pain after consumption of an ergothioneine-containing nutritional supplement. Prev Med. 2012;54 Suppl:S83-S89. doi:10.1016/j.ypmed.2012.02.001
    31. Calvo MS, Mehrotra A, Beelman RB, et al. A Retrospective Study in Adults with Metabolic Syndrome: Diabetic Risk Factor Response to Daily Consumption of Agaricus bisporus (White Button Mushrooms). Plant Foods Hum Nutr. 2016;71(3):245-251. doi:10.1007/s11130-016-0552-7
    32. Yang NC, Lin HC, Wu JH, et al. Ergothioneine protects against neuronal injury induced by β-amyloid in mice. Food Chem Toxicol. 2012;50(11):3902-3911. doi:10.1016/j.fct.2012.08.021
    33. Li C, Dong N, Wu B, Mo Z, Xie J, Lu Q. Dihydroberberine, an isoquinoline alkaloid, exhibits protective effect against dextran sulfate sodium-induced ulcerative colitis in mice. Phytomedicine. 2021;90:153631. doi:10.1016/j.phymed.2021.153631
    34. Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism. 2008;57(5):712-717. doi:10.1016/j.metabol.2008.01.013
    35. Abbud W, Habinowski S, Zhang JZ, et al. Stimulation of AMP-activated protein kinase (AMPK) is associated with enhancement of Glut1-mediated glucose transport. Arch Biochem Biophys. 2000;380(2):347-352. doi:10.1006/abbi.2000.1935
    36. Dai B, Ma Y, Wang W, et al. Dihydroberberine exhibits synergistic effects with sunitinib on NSCLC NCI-H460 cells by repressing MAP kinase pathways and inflammatory mediators. J Cell Mol Med. 2017;21(10):2573-2585. doi:10.1111/jcmm.13178
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AIM-01™ Daily Restorative:

Advanced Inflammation Management.

For Longevity & Pain Relief

Daily inflammation management for adults 18+ with three patented ingredients clinically and scientifically studied to reduce chronic inflammation and reverse markers of biological aging.*

START NOW AT $43.50 / month
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